OUR NEW PRE-PRINTS
Pumroy R.A., Samanta A., Liu Y., Hughes T., Zhao S., Yudin Y., Huynh K.W., Zhou Z.H., Rohacs T., Han S., Moiseenkova-Bell V.Y. Molecular mechanism of TRPV2 channel modulation by cannabidiol. Submitted. doi: https://doi.org/10.1101/521880
OUR PUBLICATIONS
Hughes T.E.T., Pumroy R.A., Yazici A.T., Kasimova M.A., Fluck E.C., Huynh K.W., Samanta A., Molugu S., Zhou Z.H., Carnevale V., Rohacs T., Moiseenkova-Bell V.Y. Structural insights on TRPV5 gating by endogenous modulators. Nature Communications, 9 (1):4198, 2018 doi: 10.1038/s41467-018-06753-6.
Samanta A., Kiselar J, Pumroy R.A., Han S., Moiseenkova-Bell V.Y. Structural insights into molecular mechanism of TRPA1 activation and inhibition. J. Gen. Physiology, 150(5):751-762, 2018.
Samanta A., Hughes T.E.T., Moiseenkova-Bell V.Y. Cryo electron microscopy of TRP channels, Methods in Molecular Biology, Springer, in press.
Samanta A., Hughes T., Moiseenkova-Bell V.Y. Transient Receptor Potential (TRP) Channels. Subcellular Biochemistry, 87:141-165, 2018. doi: 10.1007/978-981-10-7757-9_6.
Basak S., Gicheru Y., Samanta A., Molugu S., Huang W., De la Fuente M., Hughes T.E.T., Taylor D.J., Nieman M., Moiseenkova-Bell V.Y., Chakrapani S. Cryo-EM structure of the full-length 5-HT3A receptor in its resting conformation. Nature Communication, 514 (2018) doi:10.1038/s41467-018-02997-4.
Hughes T.E.T., Lodowski D.T., Huynh K.W., del Rosario J., Yazici A., Kapoor A., Basak S., Samanta A., Han X., Chakrapani S., Zhou Z.H., Filizola M., Rohacs T., Han S., Moiseenkova-Bell V.Y. Structural basis of the TRPV5 channel inhibition revealed by cryo-EM. Nature Structural & Molecular Biology, (1):53-60, 2018. doi: 10.1038/s41594-017-0009-1. Epub 2018 Jan 1.
Arne J.M., Widjaja-Adhi M.A., Hughes T., Huynh K.W., Silvaroli J.A., Chelstowska S., Moiseenkova-Bell V.Y., Golczak M. Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (AWAT2). Journal of Lipid Research, doi: 10.1194/jlr.M073692, 2017. Epub Jan 17 2017.
Huynh K.W., Cohen M.R., Jiang J., Samanta A., Lodowski D.T., Zhou Z.H., Moiseenkova-Bell V.Y. Structure of the full-length TRPV2 channel by cryoEM. Nature Communications, 7:11130. doi: 10.1038/ncomms11130, 2016. Epub Mar 29 2016.
Cohen M.R., Johnson W.M., Pilat J.M., Kiselar J., DeFrancesco-Lisowitz A., Zigmond R.E., Moiseenkova-Bell V.Y. NGF regulates TRPV2 via ERK signaling to enhance neurite outgrowth in developing neurons. Molecular and Cellular Biology, 35 (24):4238-4252, 2015. Epub Sep 28 2015.
Cohen M.R, Moiseenkova-Bell V.Y. Structure of thermally activated TRP channels. Current Topics in Membranes, 74:181-211, 2014.
Huynh K.W., Cohen M.R., Moiseenkova-Bell V.Y. Application of amphipols for structure-functional analysis of TRP channels. Journal of Membrane Biology, 247(9-10):843-851, 2014. Epub June 4 2014.
Cohen M.R., Huynh K.W., Cawley D., Moiseenkova-Bell V.Y Understanding the cellular function of TRPV2 channel through generation of specific monoclonal antibodies. PLoS One, 8(12):e85392, Dec 31 2013.
Huynh K.W., Cohen M.R., Chakrapani S., Holdaway H.A., Stewart P.L., Moiseenkova-Bell V.Y Structural insight into the assembly of TRPV channels. Structure, 22 (2):260-268, 2014. Epub Dec 24 2013.
Wang L., Cvetkov T.L., Chance M.R., Moiseenkova-Bell V.Y. Identification of in vivo disulfide conformation of the TRPA1 ion channel. J. Biol. Chem., 287(9):6169-76, 2012.
Cvetkov T.L., Huynh K., Cohen M., Moiseenkova-Bell V.Y. Molecular architecture and subunit organization of TRPA1 channel revealed by electron microscopy. J. Biol. Chem., 286(44):38168-76, 2011. Epub Sep 9 2011.
Jastrzebska B., Ringler P., Lodowski D., Moiseenkova-Bell V., Golczak M., Müller S.A., Palczewski K., Engel A. Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J. Struct. Biol., 176(3):387-94, 2011. Epub Sep 6 2011.
Moiseenkova-Bell V., Wensel, T.G. Functional and structural studies of TRP channels heterologously expressed in budding yeast. Advances in Experimental Medicine and Biology, 704:25-40, 2011.
Moiseenkova-Bell V.Y., Wensel T.G. Hot on the trail of TRP channel structure. J.Gen. Physiol., 133 (3): 239-244, 2009.
Moiseenkova-Bell V.Y., Stanciu L., Serysheva I., Tobe B., Wensel T.G. Structure of TRPV1 channel revealed by electron cryomicroscopy. PNAS USA, 105 (21): 7451-7455, 2008.
Moiseenkova V.Y., Hellmich H., Christensen B.N. Overexpression and purification of the vanilloid receptor in yeast (Saccharomyces cerevisiae). Biochem. Biophys. Resear.Comm., 310: 196-201, 2003.