We are in the Department of Systems Pharmacology and Translational Therapeutics  at the Perelman School of Medicine University of Pennsylvania. We are interested in understanding structure and function of Transient Receptor Potential (TRP) channels which have been implicated in a diverse range of cellular processes, including pain sensation, neuronal development, cardiovascular and renal pathophysiology, and cancer. Currently, the Moiseenkova-Bell laboratory has two main areas of research: First is to determine the structural basis of TRP channel activation, inhibition and desensitization mechanisms by utilizing cryo electron microscopy (cryo-EM). Second is to understand how TRP channels regulate cellular functions and the role of their dysregulation in human disease.

Lab Members

Cryo-EM at Penn